Vriligy 60 mg tablet is very used for ejaculation (PE) because it's a rapid onset of action, peak effect in 1-2 hours and a brief half-life, which implies it's quickly eliminated from the body within 24 hours. Going. When arousal reaches a particular threshold, nervus cells within the medulla spinalis are activated and nerve impulses are sent to the brain, which then sends messages to the motor neurons that control the muscles within the penis that affect ejaculation.