kirazmattson
87 posts
Jul 24, 2024
10:59 PM
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The half-life of Fildena 120 Mg, which contains the active ingredient Sildenafil Citrate, is approximately 3 to 5 hours. The half-life refers to the time it takes for the concentration of the drug in the bloodstream to reduce by half. Key Points About the Half-Life of Sildenafil Citrate Absorption: Sildenafil is rapidly absorbed after oral administration, with maximum plasma concentrations reached within 30 to 120 minutes (median 60 minutes) of a single oral dose in the fasted state. Duration of Action: While the half-life is 3 to 5 hours, the duration of its therapeutic effects (ability to achieve an erection) Fildena 120 last up to 4 to 6 hours after taking the dose. However, this can vary based on individual factors such as metabolism, age, and overall health. Elimination: Sildenafil is metabolized primarily by the liver (via the cytochrome P450 enzymes, mainly CYP3A4 and CYP2C9). It is excreted as metabolites predominantly in the feces (about 80% of the administered oral dose) and to a lesser extent in the urine (about 13% of the administered oral dose). Factors Affecting the Half-Life Several factors can influence the half-life of Sildenafil Citrate in the body: Age: Elderly individuals may have a longer half-life due to decreased metabolic and excretory functions. Liver Function: Impaired liver function can prolong the half-life, as the drug is primarily metabolized in the liver. Kidney Function: Impaired kidney function can also affect the excretion of the drug and its metabolites. Concurrent Medications: Some medications, especially those that inhibit or induce the CYP3A4 enzyme, can alter the metabolism and half-life of Sildenafil. Clinical Implications Understanding the half-life of Fildena 120 Mg helps in determining the dosing schedule and frequency. It is important to adhere to the prescribed dosage and frequency to avoid potential side effects and ensure the medication’s effectiveness. If you have any specific concerns or conditions that might affect how your body processes Sildenafil Citrate, consult with your healthcare provider for personalized advice and adjustments to your medication regimen.
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