Guest
Guest
Nov 25, 2025
11:38 PM
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Malegra 100 mg contains Sildenafil citrate, a PDE5 inhibitor widely used to treat erectile dysfunction (ED). Its mechanism of action is closely linked to the molecule cyclic guanosine monophosphate (cGMP), which plays a key role in regulating blood flow in the penis.
During sexual arousal, the body releases nitric oxide (NO) in the penile tissues. NO activates an enzyme called guanylate cyclase, which increases levels of cGMP. Elevated cGMP causes the smooth muscles of the penile arteries and corpus cavernosum to relax, allowing more blood to flow in, leading to an erection.
MALEGRA 100 works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). PDE5 normally breaks down cGMP, reducing its concentration and ending the erection. By blocking PDE5, Malegra prevents cGMP degradation, allowing it to accumulate and sustain the relaxation of penile smooth muscles. This prolongs and enhances the erectile response during sexual stimulation.
It’s important to note that Malegra does not trigger erections spontaneously; sexual arousal is still required to initiate NO release and cGMP production. Common side effects include headache, flushing, dizziness, nasal congestion, or upset stomach, which are usually mild and temporary.
In short, Malegra 100 mg affects cGMP levels by blocking its breakdown, thereby enhancing natural erectile mechanisms and improving erectile function.
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